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Prospective

Researchers: Immunology - University of Pennsylvania

Belkaid, Yasmine - Role of regulatory T cells during infections

Bosselut, Remy, M.D., Ph.D. - Genetic analysis of intrathymic T-cell development

Caspi, Rachel, Ph.D. - Self-tolerance and autoimmunity with a focus on immunologically privileged retinal antigens.

Douek, Daniel, M.D., Ph.D. - Analysis of T cell immune responses in humans in order to develop strategies to amplify, broaden or focus T cell immunity to HIV infection, vaccine development

Garboczi, David, N., Ph.D. - Structural Biology of membrane proteins and the T-Cell Receptor.

Germain, Ronald, M.D., Ph.D. - Peptide complexes with MHC molecules; self-peptide:MHC molecule recognition in development of thymic T cells; biochemical mechanisms of TCR discrimination between self and foreign peptide associated MHC molecules

Lenardo, Michael, M.D. - Programmed cell death in immunological tolerance, autoimmunity, and viral pathogenesis by HIV

O'Shea, John, M.D.  - Cytokine signal transduction and the molecular basis of immunoregulation

Pierce, Susan, Ph.D.  - B cell signaling, vaccine development, malaria

Paul, William E., M.D. - Mechanisms of action of type I cytokines, principally IL-4, biologic functions of cytokines, differentiation of naive T cells

Samelson, Lawrence, M.D.  - Signal Transduction Events Mediated by the T Cell Antigen Receptor     

Seder, Robert, M.D.  - Development of vaccines for infectious diseases; cellular and molecular mechanisms by which various cytokines and costimulatory molecules regulate cellular immunity in vivo  

Schwartzberg, Pamela, M.D., Ph.D. - Signal transduction pathways of cytoplasmic tyrosine kinases; defects in these pathways contributing to disease processes.

Sher, Alan, Ph.D. - Immune regulation in parasitic and bacterial infections.

Siegel, Richard, M.D., Ph.D. - TNF-receptor family signaling in normal and pathological immune responses, crosstalk between cell-death and survival signals

Singer, Alfred, M.D. - Lymphocyte recognition and development, molecular and cellular recognition signals in self/non-self discrimination in thymic development

Staudt, Louis, M.D., Ph.D. - Molecular pathogenesis of human leukemias, BCL-6 oncogene in large-cell lymphoma, micro-arrays of gene expression in human lymphomas and leukemias

Sun, Peter, Ph.D. - Structural Biology of NK cell receptors and TGF-ß receptors.

Waldmann, Thomas, M.D. - The IL-2/IL-15 Receptor System